基于改进的最大似然法识别风力发电机转子的载荷参数

风机不对中故障是多载荷参数耦合而成,工程师难以凭经验了解载荷参数的大致范围。针对因转子结构参数和测试条件等不确定性参数的存在及载荷参数先验信息未知,最大似然法识别转子不对中故障的载荷参数时采用的搜索计算面临计算量大,且迭代过程中灵敏度会带来一些数值问题。引入搜索区间进退法到敏感矩阵法与最大似然法中,对最大似然法进行改进。改进后的最大似然法中的迭代适于处理复杂工程优化问题,避免传统迭代数值法对搜索空间的苛刻要求。以输入尺寸和输出测试响应具有随机性测量误差的风力发电机转子系统为例,在三种测量误差下的识别结果表明,改进的最大似然法提高了最大似然法的辨识效果,可以减少不确定性因素对识别结果的影响,鲁棒性好。     

桩土复合路基静载试验改进方法研究

静载试验作为复合路基的一种重要检测手段而广泛应用,然而,在工程质量检测中,常出现检测结果与实际情况不符的情况,除人为操作因素外,垫层模拟过于简单是主要原因。借助引入弹性垫层,提出一种桩土复合路基静载试验改进方法。首先,基于数值模拟计算,建立复合路基桩土应力比n和桩土相对位移Δs、弹性垫层厚度h和弹性垫层模量E的函数关系;其次,通过模拟结果和路堤荷载结果对比,确定不同桩型复合路基静载试验中弹性垫层参数选择范围,最后,利用现场对比试验和实测结果,论证桩土复合路基静载试验改进方法的正确性和可靠性。     

How does FtsZ’s treadmilling help bacterial cells divide?

Most bacteria assemble a ring-like macromolecular machinery scaffolded by the essential cytoskeletal protein FtsZ for cell division. Studies have broadly explored how FtsZ could polymerize at the correct place and time. Recently, the FtsZ-ring was found to exhibit dynamic treadmilling along the circumference of the division site, driven by GTP hydrolysis. This apparently directional motion of FtsZ seems to drive the movement of septal cell wall synthesis enzymes and to play an important role in modulating cell envelope constriction and septum morphogenesis. However, the relationship between FtsZ’s treadmilling dynamics and cell wall synthesis varies in different bacteria. More importantly, the biophysical and molecular mechanisms governing these dynamic processes are unclear. In this viewpoint, we will focus on some new and exciting studies surrounding this topic and discuss potential mechanisms that underlie how FtsZ’s treadmilling dynamics might regulate septal cell wall synthesis and cell division.     

miR-181b promotes the oncogenesis of renal cell carcinoma by targeting TIMP3

Renal cell carcinoma (RCC) has a poor prognosis due to limited diagnosis and treatment. Thus, it is necessary to find novel prognostic biomarkers and therapeutic targets. The aberrant expression of microRNAs plays an important role in RCC oncogenesis. Tissue inhibitors of metalloproteinase 3 (TIMP3) acts as a downstream target of miR-181b. The aim of this study was to understand the role and molecular mechanism of miR-181b in RCC oncogenesis. The results showed that miR-181b expression was significantly higher in RCC tumour tissues, especially in those with significant invasion or metastasis. miR-181b overexpression promoted proliferation and migration of the RCC cell line 786-O, while miR-181b knockdown had the opposite effect. In addition, miR-181b was inversely correlated with TIMP3 expression in RCC tumour tissues. miR-181b overexpression reduced TIMP3 expression in RCC cell line 786-O or OS-RC-2, while miR-181b knockdown had the inverse effect. Mechanistically, a luciferase reporter assay confirmed the binding sites of miR-181b on the 3’-UTR of TIMP3, confirming the targeting effect of miR-181b on TIMP3. Overall, miR-181b promotes the development and progression of RCC by targeting TIMP3 expression, indicating the potential use of miR-181b in the diagnosis and treatment of RCC.     

真空热处理炉布料矩阵优化仿真分析

为了获得更高的加热效率和更好的温度均匀性,采用有限元软件建立了真空热处理炉加热过程仿真模型,并耦合PID算法用于温度控制。通过与实测温度对比,验证了仿真模型的准确性。借助该模型,模拟研究了布料矩阵对两种典型形状零件在真空热处理炉内加热特性的影响。模拟装炉时基于零件几何形状特征,对圆棒形工件采用顺排、叉排和环形排列3种形式,对圆盘形工件采用横排式和竖排式。研究结果表明:尽管零件形状和数量相同,但是随着布料矩阵的变化,加热效率和温度均匀性都会改变。对于圆棒形工件,采用环形排列不仅可以提高内部工件的加热速率,而且相较于叉排式可以将最大温差减小36 ℃;对于圆盘形工件,由水平式改为竖直式布料可以将最大温差由248 ℃减小至171 ℃。     

Evaluation of back-calculated elastic moduli of unreinforced and geocell-reinforced unbound granular material from full-scale field tests

This paper presents a field-scale experimental track over a poor subgrade with an unreinforced section and a geocell-reinforced section subjected to in-situ performance tests. Plate load tests and Benkelman beam tests were carried out distributed in several unreinforced and reinforced layers. The objective was to: (1) examine the variability of the elastic modulus of unbound granular material (UGM) due the influence of its thickness and the presence of poor subgrade in its base, (2) evaluate the modulus improvement factor (MIF) generated by the geocell reinforcement in the UGM and (3) verify the most appropriate condition to apply the MIF to transport infrastructure design. The results showed that there is a significant influence of the thickness of the UGM layer on its elastic modulus when the layer is supported directly over a soft subgrade. The MIF values obtained in field suggest that its determination is mostly related to the UGM maximum elastic modulus rather than its decreased values (by virtue of poor subgrade or reduced thicknesses), and that the analytical formulation presented for MIF calculation has good predictive capability to be applied to pavement design.     

Finite element limit analysis of load-bearing performance of reinforced slopes using a non-associated flow rule

This paper presents a numerical study on the load-bearing performance of reinforced slopes under footing load using a finite element limit analysis (FELA) method where a non-associated flow rule is assumed in the analysis. The method was validated against results from full-scale model tests and a limit equilibrium (LE) analytical method. A series of parametric analyses was subsequently carried out to examine the influences that the soil dilation angle, footing location, and reinforcement design (i.e. length, tensile strength, and vertical spacing) could have on the load-bearing performance of reinforced slopes. Results indicate that dilation angle has a significant influence on the predicted magnitudes of bearing capacity, slope deformation, and mobilized reinforcement load. The predicted values of bearing capacity using the FELA are smaller than those from the Meyerhof's analytical method for unreinforced semi-infinite foundation, especially for larger friction angle values. Additionally, the ultimate bearing capacity of the slope and its corresponding horizontal deformation increase with the reinforcement tensile strength. Finally, the slip planes under the applied footing load are found to be y-shaped and primarily occur in the upper half of the slope.     

Manual patient transfers: factors that influence decisions and kinematic strategies employed by nursing aides

While extensive literature has characterised factors that influence the acceptable mass of ‘boxes’ during MMH tasks, less is known about these factors when moving ‘people’ in healthcare settings. This study examined factors that influence decisions/approaches employed during manual patient transfers. Sixteen nursing aides manually-transferred a standardised ‘patient’; patient mass was adjusted (using a weight vest) to determine a maximum acceptable patient mass for this task (mass_max). Grip strength was the only worker characteristic significantly associated with mass_max (r?=?0.48). Older worker age was associated with smaller peak trunk flexion (r?= ?0.58) and shoulder abduction (r?= ?0.59), and greater trunk axial twist (r?=?0.52). Workers emphasised that patient characteristics (e.g. physical/cognitive status) influenced their decisions when performing transfers. These findings extend previous literature by suggesting that grip strength is a useful predictor of perceived work capacity, older workers adapt protective postural strategies during patient transfers and worker-patient dynamics are crucial during this high-risk occupational task.

Practitioner Summary: This study examined manual patient transfers performed by nursing aides. Worker grip strength (but not age or size) was associated with perceptions of maximum acceptable patient mass. Kinematic changes suggested more conservative strategies used by older workers. Workers emphasised that patient characteristics substantially influenced their decisions when performing transfer tasks.     

A review on the features and technologies for energy efficiency of smart grid

In today's world striving for efficiency in every sector, especially power generation and distribution, smart grids emerge as the solution for efficiently meeting the increasing demand. They adjust themselves to optimally deliver energy at the lowest cost and highest quality possible. The grid successfully makes use of renewable energy resources, electric vehicles, and smart pricing techniques in its attempt to achieve energy efficiency. It also promotes a greener environment by striving to reduce greenhouse gas emissions. Information communication technology (ICT) helps the grid in collecting consumption data from the consumers and in sharing tariff information. ICT also helps to gather information about the status of the grid with regard to aspects like power quality, faults etc. The purpose of this paper is to review recent literature with a view to comprehensively present the technologies employed in the smart grid for achieving energy efficiency and the challenges involved therein.